(19)

(11)

EP 2 016 057 A1

(12)

(43) Date of publication: 21.01.2009 Bulletin 2009/04 (21) Application number: 06758435.9 (22) Date of filing: 20.04.2006

(51) International Patent Classification (IPC):  C07D 233/90(2006.01) C07D 405/12(2006.01) A61K 31/501(2006.01) C07D 401/12(2006.01) C07D 403/12(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2006/014886 (87) International publication number: WO 2007/123516 (01.11.2007 Gazette 2007/44)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (71) Applicant: Janssen Pharmaceutica NV 2340 Beerse (BE)

(72) Inventors: PLAYER, Mark, R. Phoenixville, Pennsylvania 19460 (US) BAINDUR, Nand Kendall Park, New Jersey 08824 (US) BRANDT, Benjamin, M. Philadelphia, Pennsylvania 19119 (US) CHADHA, Naresh Montville, New Jersey 07045 (US) PATCH, Raymond, J. Yardley, Pennsylvania 19067 (US) ASGARI, Davoud Plainsboro, New Jersey 08536 (US) GEORGIADIS, Taxiarchis Carmel, Indiana 46033 (US) (74) Representative: Warner, James Alexander et al Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)