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(11)

EP 2 016 061 A1

(12)

(43) Date of publication: 21.01.2009 Bulletin 2009/04 (21) Application number: 07728463.6 (22) Date of filing: 24.04.2007

(51) International Patent Classification (IPC):  C07D 263/48(2006.01) C07D 417/12(2006.01) A61K 31/426(2006.01) A61P 25/00(2006.01) C07D 277/42(2006.01) A61K 31/421(2006.01) A61K 31/427(2006.01) (86) International application number: PCT/EP2007/054007 (87) International publication number: WO 2007/122241 (01.11.2007 Gazette 2007/44)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 26.04.2006 GB 0608272 (71) Applicant: Glaxo Group Limited Greenford Middlesex UB6 0NN (GB)

(72) Inventors: BRADLEY, Daniel Marcus Harlow Essex CM19 5AW (GB) CHAN, Wai Ngor Harlow Essex CM19 5AW (GB) HARRISON, Stephen Harlow Essex CM19 5AW (GB) HUGHES, Owen Stevenage Hertfordshire SG1 2NY (GB) MILLER, David Drysdale Stevenage Hertfordshire SG1 2NY (GB) NEESOM, James Stevenage Hertfordshire SG1 2NY (GB) THEWLIS, Kevin Michael Harlow Essex CM19 5AW (GB) WARD, Simon Edward Harlow Essex CM19 5AW (GB) (74) Representative: Kondo, Rie  GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)