(19)

(11)

EP 2 016 062 A2

(12)

(88) Date of publication A3: 27.03.2008 (43) Date of publication: 21.01.2009 Bulletin 2009/04 (21) Application number: 07755981.3 (22) Date of filing: 25.04.2007

(51) International Patent Classification (IPC):  C07D 277/20(2006.01) C07D 333/38(2006.01) A61K 31/426(2006.01) C07D 333/36(2006.01) A61K 31/381(2006.01) A61P 31/12(2006.01) (86) International application number: PCT/US2007/009959 (87) International publication number: WO 2007/127212 (08.11.2007 Gazette 2007/45)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 25.04.2006 US 795069 P (71) Applicant: The Cleveland Clinic Foundation Beachwood, OH 44122 (US)	(72) Inventors: SILVERMAN, Robert Beachwood, OH 44121 (US) TORRENCE, Paul Williams, OR 97544 (US) JHA, Babal, Kant Cleveland, OH 44120 (US) FRANCOM, Paula Notting Hill, VIC 3168 (AU) (74) Representative: Stevens, Ian Edward  Potter Clarkson LLP Park View House 58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)