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(11)

EP 2 016 417 A1

(12)

(43) Date of publication: 21.01.2009 Bulletin 2009/04 (21) Application number: 07724624.7 (22) Date of filing: 26.04.2007

(51) International Patent Classification (IPC):  G01N 33/68(2006.01) C12Q 1/68(2006.01) A61K 48/00(2006.01) G01N 33/574(2006.01) A61K 38/00(2006.01) (86) International application number: PCT/EP2007/003694 (87) International publication number: WO 2007/128429 (15.11.2007 Gazette 2007/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 28.04.2006 GB 0608483 (71) Applicant: NOVARTIS AG 4056 Basel (CH)	(72) Inventors: BOBADILLA, Maria 68220 Hésingue (FR) CHIBOUT, Salah-Dine 68720 Tagolsheim (FR) CORDIER, André 4054 Basel (CH) (74) Representative: Bourgarel, Denis Jacques Marie et al Novartis Pharma AG Patent Department CH-4002 Basel CH-4002 Basel (CH)