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EP 2 016 419 A2

(12)

(88) Date of publication A3: 10.01.2008 (43) Date of publication: 21.01.2009 Bulletin 2009/04 (21) Application number: 07728843.9 (22) Date of filing: 07.05.2007

(51) International Patent Classification (IPC):  G01N 33/68(2006.01) G01N 33/569(2006.01) A61K 39/21(2006.01) C07K 14/16(2006.01) A61K 38/16(2006.01) (86) International application number: PCT/EP2007/054390 (87) International publication number: WO 2007/128806 (15.11.2007 Gazette 2007/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 10.05.2006 EP 06300450 (71) Applicants: INSERM (Institut National de la Santé et de la Recherche Medicale) 75013 Paris (FR) Université René Descartes - Paris 5 75270 Paris Cedex 06 (FR) Centre National de la Recherche Scientifique 75794 Paris Cedex 16 (FR)

(72) Inventors: BERLIOZ-TORRENT, Clarisse 75016 Paris (FR) BENAROUS, Richard 75013 Paris (FR) LOPEZ-VERGES, Sandra 75011 Paris (FR) (74) Representative: Catherine, Alain et al Cabinet Harlé & Phélip 7 rue de Madrid 75008 Paris 75008 Paris (FR)