(19)

(11)

EP 2 021 330 A2

(12)

(88) Date of publication A3: 14.02.2008 (43) Date of publication: 11.02.2009 Bulletin 2009/07 (21) Application number: 07760746.3 (22) Date of filing: 17.04.2007

(51) International Patent Classification (IPC):  C07D 235/08(2006.01) C07D 403/06(2006.01) A61K 31/4706(2006.01) C07D 401/06(2006.01) A61K 31/4184(2006.01) A61P 29/00(2006.01) (86) International application number: PCT/US2007/066748 (87) International publication number: WO 2007/130780 (15.11.2007 Gazette 2007/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 03.05.2006 US 797504 P (71) Applicant: Janssen Pharmaceutica, N.V. 2340 Beerse (BE)

(72) Inventors: CALVO, Raul, L. Royersford, Pennsylvania 09468 (US) PLAYER, Mark, R. Phoenixville, Pennsylvania 19460 (US) DAX, Scott, L. Landenberg, Pennsylvania 09350 (US) PARSONS, William, H. Belle Mead, New Jersey 08502 (US) BRANDT, Michael Flemington, New Jersey 08822 (US) PATEL, Sharmila Jamison, Pennsylvania 18929 (US) LIU, Jian Manalapan, New Jersey 07726 (US) CHEUNG, Wing, S. Plainsboro, New Jersey 08536 (US) JETTER, Michele, C. Norristown, Pennsylvania 19403 (US) LEE, Yu-kai Exton, Pennsylvania 19341 (US) YOUNGMAN, Mark, A. Warminster, Pennsylvania 18974 (US) PAN, Wenxi Glenmoore, Pennsylvania 19343 (US) WELLS, Kenneth, M. Hillsborough, New Jersey 08844 (US) BEAUCHAMP, Derek, A. Watchung, New Jersey 07069 (US) (74) Representative: Warner, James Alexander et al Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)