(19)
(11) EP 2 021 364 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.05.2014 Bulletin 2014/21

(45) Mention of the grant of the patent:
09.04.2014 Bulletin 2014/15

(21) Application number: 07748141.4

(22) Date of filing: 15.05.2007
(51) International Patent Classification (IPC): 
C07K 14/47(2006.01)
A61K 38/10(2006.01)
C07K 7/08(2006.01)
C07K 5/08(2006.01)
C07K 5/10(2006.01)
 A61K 38/04(2006.01)
A61P 31/04(2006.01)
A61K 38/17(2006.01)
C12N 15/62(2006.01)
(86) International application number:
PCT/SE2007/000477
(87) International publication number:
WO 2007/133153 (22.11.2007 Gazette 2007/47)

(54)

IMPROVED ANTIMICROBIAL PEPTIDES

VERBESSERTE ANTIMIKROBIELLE PEPTIDE

PEPTIDES ANTIMICROBIENS AMÉLIORÉS

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

(30) Priority: 16.05.2006 SE 0601088
16.05.2006 US 800644 P

(43) Date of publication of application:
11.02.2009 Bulletin 2009/07

(73) Proprietor: Pergamum AB
171 65 Solna (SE)

(72) Inventors:
  • SCHMIDTCHEN, Artur
    222 41 Lund (SE)
  • MALMSTEN, Martin
    187 35 Täby (SE)

(74) Representative: Brann AB 
P.O. Box 12246
102 26 Stockholm
102 26 Stockholm (SE)


(56) References cited: : 
WO-A1-00/01427
WO-A1-2005/061535
WO-A2-96/28468
WO-A2-2006/035431
 WO-A1-00/01427
WO-A1-2006/050611
WO-A2-03/018619
DE-A1- 10 160 170
   
  • NORDAHL E A ET AL: "Domain 5 of High Molecular Weight Kininogen Is Antibacterial" JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM, US, vol. 280, no. 41, 14 October 2005 (2005-10-14), pages 34832-34839, XP003016814 ISSN: 0021-9258
  • SITARAM N: "Antimicrobial peptides with unusual amino acid compositions and unusual structures" CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 13, no. 6, 1 January 2006 (2006-01-01), pages 679-696, XP009108304 ISSN: 0929-8673
  • LEQUIN OLIVIER ET AL: "Dermaseptin S9, an alpha-helical antimicrobial peptide with a hydrophobic core and cationic termini" BIOCHEMISTRY, vol. 45, no. 2, January 2006 (2006-01), pages 468-480, XP002550287 ISSN: 0006-2960
  • OSTRESH J M ET AL: "Libraries from libraries: Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 91, 1 November 1994 (1994-11-01), pages 11138-11142, XP002096988 ISSN: 0027-8424
  • BOGGIANO C ET AL: "SUCCESSFUL IDENTIFICATION OF NOVEL AGENTS TO CONTROL INFECTIOUS DISEASES FROM SCREENING MIXTURE-BASED PEPTIDE COMBINATORIAL LIBRARIES IN COMPLEX CELL-BASED BIOASSAYS" BIOPOLYMERS, NEW YORK, NY, US, vol. 71, no. 2, 1 January 2003 (2003-01-01), pages 103-116, XP001172836 ISSN: 0006-3525
  • LÓPEZ-GARCÍA B ET AL: "Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library" APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 68, no. 5, 1 May 2002 (2002-05-01), pages 2453-2460, XP002398048 ISSN: 0099-2240
  • DATABASE WPI Week 200444 Thomson Scientific, London, GB; AN 2004-464559 XP002550288 -& JP 2004 175727 A (TOA GOSEI CHEM IND LTD) 24 June 2004 (2004-06-24)
  • LOHNER K ET AL: "Molecular mechanisms of membrane perturbation by antimicrobial peptides and the use of biophysical studies in the design of novel peptide antibiotics" COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, vol. 8, no. 3, May 2005 (2005-05), pages 241-256, XP008113208 ISSN: 1386-2073
  • MALMSTEN MARTIN ET AL: "Antimicrobial peptides derived from growth factors" GROWTH FACTORS, HARWOOD ACADEMIC PUBLISHERS GMBH, XX, vol. 25, no. 1, 1 January 2007 (2007-01-01), pages 60-70, XP009114169 ISSN: 0897-7194
  • MAKOVITZKI ARIK ET AL: "Ultrashort antibacterial and antifungal lipopeptides" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 103, no. 43, 1 October 2006 (2006-10-01), pages 15997-16002, XP009096818 ISSN: 0027-8424
  • SCHMIDTCHEN ARTUR ET AL: "Boosting Antimicrobial Peptides by Hydrophobic Oligopeptide End Tags" JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 26, June 2009 (2009-06), pages 17584-17594, XP002550290 ISSN: 0021-9258
  • STRÖMSTEDT ADAM A ET AL: "Oligotryptophan-tagged antimicrobial peptides and the role of the cationic sequence." BIOCHIMICA ET BIOPHYSICA ACTA SEP 2009, vol. 1788, no. 9, September 2009 (2009-09) , pages 1916-1923, XP002550291 ISSN: 0006-3002
  • PASUPULETI MUKESH ET AL: "End-Tagging of Ultra-Short Antimicrobial Peptides by W/F Stretches to Facilitate Bacterial Killing" PLOS ONE, vol. 4, no. 4, April 2009 (2009-04), XP002550292 ISSN: 1932-6203
  • TOSSI A. ET AL.: 'Amphipathic, alfa-Helical Antimicrobial Peptides' BIOPOLYMERS (PEPTIDE SCIENCE) vol. 55, 2000, pages 4 - 30, XP001000420
  • NORDAHL E.A. ET AL.: 'Domain 5 of High Molecular Weight Kininogen Is Antibacterial' THE JOURNAL OF BIOLOGICAL CHEMISTRY vol. 280, no. 41, 14 October 2005, pages 34832 - 34839, XP003016814
  • ANDERSSON E. ET AL.: 'Antimicrobial activities of heparin-binding peptides' EUR. J. BIOCHEM. vol. 271, 2004, pages 1219 - 1226, XP002903811
  • MALMSTEN MARTIN ET AL: "Highly Selective End-Tagged Antimicrobial Peptides Derived from PRELP", PLOS ONE, vol. 6, no. 1, January 2011 (2011-01), page Article No.: e16400, ISSN: 1932-6203
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).