(19)
(11) EP 2 021 794 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
18.08.2010 Bulletin 2010/33

(45) Mention of the grant of the patent:
16.06.2010 Bulletin 2010/24

(21) Application number: 07725293.0

(22) Date of filing: 16.05.2007
(51) International Patent Classification (IPC): 
G01N 33/53(2006.01)
 C12Q 1/68(2006.01)
(86) International application number:
PCT/EP2007/004378
(87) International publication number:
WO 2007/134779 (29.11.2007 Gazette 2007/48)

(54)

USE OF PROTEIN S100A 12 AS A MARKER FOR COLORECTAL CANCER

VERWENDUNG DES PROTEINS S100A 12 ALS MARKER FÜR KOLOREKTALKARZINOM

UTILISATION DE LA PROTÉINE S100A 12 EN TANT QUE MARQUEUR DU CANCER DU CÔLON ET DU RECTUM

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

(30) Priority: 19.05.2006 EP 06010439

(43) Date of publication of application:
11.02.2009 Bulletin 2009/07

(73) Proprietors:
  • Roche Diagnostics GmbH
    68305 Mannheim (DE)
    Designated Contracting States:
    DE 
  • F.HOFFMANN-LA ROCHE AG
    4070 Basel (CH)
    Designated Contracting States:
    AT BE BG CH LI CY CZ DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC MT NL PL PT RO SE SI SK TR 

(72) Inventors:
  • WILD, Norbert
    82538 Geretsried (DE)
  • ANDRES, Herbert
    82377 Penzberg (DE)
  • GARCZAREK, Ursula
    83671 Benediktbeuern (DE)
  • GEISTANGER, Andrea
    81477 Muenchen (DE)
  • HAGMANN, Marie-Luise
    82377 Penzberg (DE)
  • KARL, Johann
    82380 Peissenberg (DE)
  • KRAUSE, Friedemann
    82377 Penzberg (DE)
  • PFEFFER, Michael
    82377 Penzberg (DE)
  • ROLLINGER, Wolfgang
    82398 Polling (DE)
  • TACKE, Michael
    80689 Muenchen (DE)
  • THIEROLF, Michael
    88400 Biberach (DE)


(56) References cited: : 
WO-A-2005/054508
WO-A2-2004/079368
 WO-A-2006/012588
US-A1- 2004 157 278
   
  • SIEG A ET AL: "DETECTION OF COLORECTAL NEOPLASMS BY THE HIGHLY SENSITIVE HEMOGLOBIN-HAPTOGLOBIN COMPLEX IN FECES" INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, SPRINGER VERLAG, BERLIN, DE, vol. 14, no. 6, December 1999 (1999-12), pages 267-271, XP001182520 ISSN: 0179-1958
  • GILBERT J A ET AL: "FECAL MARKER VARIABILITY IN COLORECTAL CANCER: CALPROTECTIN VERSUS HEMOGLOBIN" SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, vol. 31, 1996, pages 1001-1005, XP002053475 ISSN: 0036-5521
  • STULÍK J ET AL: "The analysis of S100A9 and S100A8 expression in matched sets of macroscopically normal colon mucosa and colorectal carcinoma: the S100A9 and S100A8 positive cells underlie and invade tumor mass." ELECTROPHORESIS. 1999 APR-MAY, vol. 20, no. 4-5, April 1999 (1999-04), pages 1047-1054, XP002407823 ISSN: 0173-0835
  • STULÍK J ET AL: "Overexpression of calcium-binding protein calgranulin B in colonic mucosal diseases." CLINICA CHIMICA ACTA; INTERNATIONAL JOURNAL OF CLINICAL CHEMISTRY. 8 SEP 1997, vol. 265, no. 1, 8 September 1997 (1997-09-08), pages 41-55, XP002403733 ISSN: 0009-8981
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).