(19)

(11)

EP 2 023 923 A2

(12)

(88) Date of publication A3: 03.07.2008 (43) Date of publication: 18.02.2009 Bulletin 2009/08 (21) Application number: 07784137.7 (22) Date of filing: 25.05.2007

(51) International Patent Classification (IPC):  A61K 31/427(2006.01) A61K 45/06(2006.01) A61K 35/00(2006.01) A61K 31/496(2006.01) A61K 31/517(2006.01) (86) International application number: PCT/US2007/069741 (87) International publication number: WO 2007/140299 (06.12.2007 Gazette 2007/49)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 25.05.2006 US 803193 P (71) Applicant: Bristol-Myers Squibb Company Princeton NJ 08543-4000 (US)	(72) Inventor: COHEN, Marvin Barry Princeton, New Jersey 08543 (US) (74) Representative: Beacham, Annabel Rose  Frank B. Dehn & Co. St Bride's House 10 Salisbury Square London EC4Y 8JD London EC4Y 8JD (GB)