(19)

(11)

EP 2 024 353 A2

(12)

(88) Date of publication A3: 16.10.2008 (43) Date of publication: 18.02.2009 Bulletin 2009/08 (21) Application number: 07705682.8 (22) Date of filing: 05.03.2007

(51) International Patent Classification (IPC):  C07D 401/04(2006.01) C07D 403/04(2006.01) C07D 405/14(2006.01) A61K 31/506(2006.01) C07D 401/14(2006.01) C07D 403/14(2006.01) A61K 31/454(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/IB2007/000561 (87) International publication number: WO 2007/105058 (20.09.2007 Gazette 2007/38)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 16.03.2006 US 782786 P 25.01.2007 US 886561 P (71) Applicant: Pfizer Products Inc. Groton, Connecticut 06340-5196 (US)

(72) Inventors: BENNET, Michael, John Agouron Pharmaceuticals Inc.A Pfizer Company San Diego, CA 92121 (US) CHO-SCHULTZ, Sujin Agouron Pharmaceuticals Inc.A Pfizer Company San Diego, CA 92121 (US) DEAL, Judith Gall Agouron Pharmaceuticals Inc.A Pfizer Company San Diego, CA 92121 (US) KING, Stephen Joseph Agouron Pharmaceuticals Inc.A Pfizer Company San Diego, CA 92121 (US) MARRONE, Tami Jo Agouron Pharmaceuticals Inc.A Pfizer Company San Diego, CA 92121 (US) PALMER, Cynthia Louise Agouron Pharmaceuticals Inc.A Pfizer Company San Diego, CA 92121 (US) ROMINES III, William Henry Agouron Pharmaceuticals Inc.A Pfizer Company San Diego, CA 92121 (US) RUI, Eugene, Yuanjin Agouron Pharmaceuticals Inc.A Pfizer Company San Diego, CA 92121 (US) SUTTON, Scott Channing Agouron Pharmaceuticals Inc.A Pfizer Company San Diego, CA 92121 (US) ZEHNDER, Luke Raymond Agouron Pharmaceuticals Inc.A Pfizer Company San Diego, CA 92121 (US) (74) Representative: Nevant, Marc  Pfizer European Patent Department 23-25, avenue du Docteur Lannelongue 75668 Paris Cedex 14 75668 Paris Cedex 14 (FR)