(19)

(11)

EP 2 024 386 A2

(12)

(88) Date of publication A3: 29.05.2008 (43) Date of publication: 18.02.2009 Bulletin 2009/08 (21) Application number: 07777374.5 (22) Date of filing: 01.06.2007

(51) International Patent Classification (IPC):  C07K 1/22(2006.01) G01N 33/543(2006.01) C07K 14/495(2006.01) C07K 17/02(2006.01) A61K 38/18(2006.01) C07K 14/51(2006.01) (86) International application number: PCT/US2007/013053 (87) International publication number: WO 2007/143161 (13.12.2007 Gazette 2007/50)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 02.06.2006 US 810798 P (71) Applicant: Wyeth Madison, NJ 07940 (US)

(72) Inventors: LU, Zhijian Bedford, MA 01730 (US) LIU, Wei Lexington, Massachusetts 02421 (US) ZHANG, Jimin Chestnut Hill, MA 02467 (US) YAWORSKY, Paul John Rockland, MA 02370 (US) BROWN, Christopher Todd Lowell, MA 01851 (US) OLLAND, Stephane H. Arlington, MA 02476 (US) SHEN, Emily Sheng-Ming West Chester, PA 19382 (US) (74) Representative: Denholm, Anna Marie  Wyeth Pharmaceuticals, Huntercombe Lane South Taplow, Maidenhead Berkshire SL6 0PH Taplow, Maidenhead Berkshire SL6 0PH (GB)