(19)

(11)

EP 2 024 389 A2

(12)

(88) Date of publication A3: 03.01.2008 (43) Date of publication: 18.02.2009 Bulletin 2009/08 (21) Application number: 07732698.1 (22) Date of filing: 04.05.2007

(51) International Patent Classification (IPC):  C07K 14/47(2006.01) A61K 38/10(2006.01) C07K 7/08(2006.01) A61K 38/08(2006.01) C07K 7/06(2006.01) (86) International application number: PCT/GB2007/001669 (87) International publication number: WO 2007/129077 (15.11.2007 Gazette 2007/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 05.05.2006 GB 0608960 (71) Applicant: St George's Hospital Medical School London SW17 0RE (GB)	(72) Inventor: AUSTEN, Brian London SW17 0RE (GB) (74) Representative: Tuxworth, Pamela M.  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)