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(11)

EP 2 024 391 A2

(12)

(88) Date of publication A3: 02.10.2008 (43) Date of publication: 18.02.2009 Bulletin 2009/08 (21) Application number: 07852376.8 (22) Date of filing: 30.05.2007

(51) International Patent Classification (IPC):  C07K 14/705(2006.01) G01N 23/20(2006.01) C30B 7/00(2006.01) G06F 19/00(2006.01) (86) International application number: PCT/US2007/012816 (87) International publication number: WO 2008/036135 (27.03.2008 Gazette 2008/13)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 01.06.2006 US 810271 P 29.06.2006 US 806225 P 21.08.2006 US 839363 P (71) Applicant: Genentech, Inc. South San Francisco CA 94080-4990 (US)

(72) Inventors: HASS, Phillip Moss Beach, CA 94038 (US) KATSCHKE, Kenneth, Jr. Millbrae, CA 94030 (US) STEFFEK, Micah Walnut Creek, CA 94596 (US) VAN LOOKEREN CAMPAGNE, Menno San Francisco, CA 94127 (US) WIESMANN, Christian Brisbane, CA 94005 (US) YIN, Jianping Foster City, CA 94404 (US) (74) Representative: Denison, Christopher Marcus  Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS London EC2V 8AS (GB)