(19)

(11)

EP 2 024 497 A2

(12)

(88) Date of publication A3: 20.09.2007 (43) Date of publication: 18.02.2009 Bulletin 2009/08 (21) Application number: 06828120.3 (22) Date of filing: 19.12.2006

(51) International Patent Classification (IPC):  C12N 15/09(2006.01) A61K 39/02(2006.01) G01N 33/53(2006.01) C07K 14/20(2006.01) (86) International application number: PCT/BR2006/000283 (87) International publication number: WO 2007/070996 (28.06.2007 Gazette 2007/26)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 19.12.2005 BR PI0505529 (71) Applicant: Fundacao Oswaldo Cruz - Fiocruz Manguinhos, CEP-21045-900 Rio de Janeiro (BR)

(72) Inventors: MEDEIROS, Marco, Alberto Encantado, Rio de Janeiro (BR) DOS REIS, mitemayer, Galvão Brotas, Salvador (BR) DA SILVA, Éverton, Fagonde Barra Avenida, Salvador (BR) MCBRIDE, Alan, John, Alexander Barra, Salvador (BR) CRODA, Julio, Henrique, Rosa Itaigara, Salvador (BR) RAMOS, João, Gabriel, Rosa Itaigara, Salvador (BR) DELLAGOSTIN, Odir, Antônio Laranjal, Pelotas (BR) MCBRIDE, Flavia, Weykamp, Cruz Salvador, BA (BR) KO, Albert, Icksang Salvador, BA (BR) (74) Representative: Ramos Lucas, Maria Manuel  MarquesMarcas, Lda. Largo de São Domingos, 1 2910-092 Setúbal 2910-092 Setúbal (PT)