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(11)

EP 2 032 143 A1

(12)

(43) Date of publication: 11.03.2009 Bulletin 2009/11 (21) Application number: 06836582.4 (22) Date of filing: 27.10.2006

(51) International Patent Classification (IPC):  A61K 31/70(2006.01) A01N 45/00(2006.01) (86) International application number: PCT/US2006/042014 (87) International publication number: WO 2007/130124 (15.11.2007 Gazette 2007/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 09.05.2006 US 799199 P (71) Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. Louisville, KY 40202 (US)	(72) Inventors: VALDES, Jr., Roland Simpsonville, KY 40067 (US) IHENETU, Kenneth Louisville, KY 40223 (US) FERNANDES-BOTRAN, Rafael Louisville, KY 40220 (US) QAZZAZ, Hassan Louisville, KY 40210 (US) (74) Representative: Beresford, Keith Denis Lewis et al BERESFORD & Co. 16 High Holborn London WC1V 6BX London WC1V 6BX (GB)