(19)

(11)

EP 2 032 578 A2

(12)

(88) Date of publication A3: 07.02.2008 (43) Date of publication: 11.03.2009 Bulletin 2009/11 (21) Application number: 07734734.2 (22) Date of filing: 18.05.2007

(51) International Patent Classification (IPC):  C07D 487/04(2006.01) A61P 35/00(2006.01) A61K 31/5025(2006.01) (86) International application number: PCT/IB2007/001446 (87) International publication number: WO 2007/138472 (06.12.2007 Gazette 2007/49)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 30.05.2006 US 803469 P (71) Applicant: Pfizer Products Incorporated Groton, CT 06340 (US)

(72) Inventors: CHENG, Hengmiao San Diego, CA 92121 (US) CUI, Jingrong Jean San Diego, CA 92121 (US) HOFFMAN, Jacqui Elizabeth San Diego, CA 92121 (US) JIA, Lei San Diego, CA 92121 (US) KANIA, Robert, Steven San Diego, CA 92121 (US) LE, Phuong Thi Quy San Diego, CA 92121 (US) NAMBU, Mitchell David San Diego, CA 92121 (US) PAIRISH, Mason Alan San Diego, CA 92121 (US) SHEN, Hong San Diego, CA 92121 (US) TRAN-DUBE, Michelle Bich San Diego, CA 92121 (US) (74) Representative: Nevant, Marc  Pfizer European Patent Department 23-25, avenue du Docteur Lannelongue 75668 Paris Cedex 14 75668 Paris Cedex 14 (FR)