(19)

(11)

EP 2 035 032 A2

(12)

(88) Date of publication A3: 16.10.2008 (43) Date of publication: 18.03.2009 Bulletin 2009/12 (21) Application number: 07809361.4 (22) Date of filing: 05.06.2007

(51) International Patent Classification (IPC):  A61K 38/46(2006.01) C12Q 1/42(2006.01) G01N 33/573(2006.01) C12N 9/18(2006.01) C12N 15/10(2006.01) C12N 15/55(2006.01) (86) International application number: PCT/US2007/013333 (87) International publication number: WO 2007/146003 (21.12.2007 Gazette 2007/51)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 07.06.2006 US 811370 P (71) Applicant: Human Biomolecular Research Institute San Diego, CA 92121-2804 (US)	(72) Inventors: CASHMAN, John, R. San Diego, CA 92121 (US) ZHANG, Jun San Diego, CA 92129 (US) (74) Representative: Weber, Martin  Jones Day Rechtsanwälte Attorneys-at-Law Patentanwälte Prinzregentenstrasse 11 80538 München 80538 München (DE)