(19)

(11)

EP 2 035 038 A2

(12)

(88) Date of publication A3: 16.10.2008 (43) Date of publication: 18.03.2009 Bulletin 2009/12 (21) Application number: 07760034.4 (22) Date of filing: 03.04.2007

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) A61K 31/10(2006.01) (86) International application number: PCT/US2007/065869 (87) International publication number: WO 2007/118084 (18.10.2007 Gazette 2007/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 03.04.2006 US 744182 P 15.09.2006 US 825873 P (71) Applicant: Stowers Institute for Medical Research Kansas City, MO 64112 (US)	(72) Inventors: LI, Xiaogang Prairie Village, KS 66208 (US) LI, Rong Kansas City, MO 64112 (US) (74) Representative: Thom, Russell  Murgitroyd & Company Scotland House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)