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EP 2 035 372 A1

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(43) Date of publication: 18.03.2009 Bulletin 2009/12 (21) Application number: 07796576.2 (22) Date of filing: 28.06.2007

(51) International Patent Classification (IPC):  C07D 207/06(2006.01) C07D 207/48(2006.01) C07D 403/12(2006.01) C07D 413/12(2006.01) C07D 419/10(2006.01) A61K 31/4439(2006.01) A61K 31/541(2006.01) A61K 31/5377(2006.01) C07D 207/12(2006.01) C07D 401/12(2006.01) C07D 405/12(2006.01) C07D 417/12(2006.01) A61K 31/4025(2006.01) A61K 31/40(2006.01) A61K 31/4409(2006.01) (86) International application number: PCT/US2007/015139 (87) International publication number: WO 2008/005338 (10.01.2008 Gazette 2008/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 29.06.2006 US 817459 P (71) Applicants: Arena Pharmaceuticals, Inc. San Diego, CA 92121-3223 (US) Park, Douglas M. Valley Center, CA 92082 (US)

(72) Inventors: SANTORA, Vincent, J. Carlsbad, California 92008 (US) COVEL, Jonathan, A. San Diego, California 92129 (US) IBARRA, Jason, B. Las Vegas, Nevada 89139 (US) SEMPLE, Graeme San Diego, California 92127 (US) SMITH, Brian San Diego, California 92129 (US) SMITH, Jeffrey San Diego, California 92131 (US) WEINHOUSE, Michael, I. Escondido, California 92029 (US) SCHULTZ, Jeffrey, A. San Diego, California 92127 (US) (74) Representative: Wytenburg, Wilhelmus Johannes et al Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS London EC2V 8AS (GB)