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EP 2 035 435 A1

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(43) Date of publication: 18.03.2009 Bulletin 2009/12 (21) Application number: 06802035.3 (22) Date of filing: 21.08.2006

(51) International Patent Classification (IPC):  C07D 497/10(2006.01) A61P 35/00(2006.01) A61K 31/39(2006.01) (86) International application number: PCT/US2006/032660 (87) International publication number: WO 2007/139569 (06.12.2007 Gazette 2007/49)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 26.05.2006 US 808861 P (71) Applicant: ARQULE, INC. Woburn, MA 01801 (US)

(72) Inventors: ASHWELL, Mark Carlisle, MA 01741 (US) TANDON, Manish Framingham, MA 01741 (US) LAPIERRE, Jean-Marc Pelham, NH 03076 (US) ALI, Syed North Andover, MA 01845 (US) VENSEL, David Somerville, MA 02144 (US) LI, Chiang J. West Roxbury, MA 02132 (US) (74) Representative: Crump, Julian Richard John et al Mintz, Levin, Cohn, Ferris, Glovsky and Popeo IP, LLP Alder Castle 10 Noble Street London EC2V 7JX 10 Noble Street London EC2V 7JX (GB)