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EP 2 038 253 A1

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(43) Date of publication: 25.03.2009 Bulletin 2009/13 (21) Application number: 07712949.2 (22) Date of filing: 21.03.2007

(51) International Patent Classification (IPC):  C07D 205/04(2006.01) C07D 233/54(2006.01) C07D 279/12(2006.01) C07D 295/22(2006.01) C07D 333/20(2006.01) A61K 31/395(2006.01) A61K 31/381(2006.01) C07D 213/75(2006.01) C07D 237/28(2006.01) C07D 295/12(2006.01) C07D 307/38(2006.01) C07D 417/12(2006.01) A61K 31/4433(2006.01) A61P 31/12(2006.01) (86) International application number: PCT/GB2007/001024 (87) International publication number: WO 2007/138242 (06.12.2007 Gazette 2007/49)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 30.05.2006 GB 0610664 30.05.2006 GB 0610663 18.09.2006 WO PCT/GB2006/003469 (71) Applicant: Arrow Therapeutics Limited London SE1 1DA (GB)

(72) Inventors: LUMLEY, James London SE1 1DA (GB) SALTER, James Iain London SE1 1DA (GB) CARTER, Malcolm Clive London SE1 1DA (GB) MATHEWS, Neil London SE1 1DA (GB) PILKINGTON, Christopher John London SE1 1DA (GB) THOMAS, Alexander James Floyd London SE1 1DA (GB) FRASER, Ian London SE1 1DA (GB) (74) Representative: Boar, Bernard Robin  AstraZeneca R&D Headquarters Global Intellectual Property 151 85 Södertälje 151 85 Södertälje (SE)