| (84) |
Designated Contracting States: |
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AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO
SE SI SK TR |
| (30) |
Priority: |
22.05.2006 EP 06290823
|
| (43) |
Date of publication of application: |
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01.04.2009 Bulletin 2009/14 |
| (73) |
Proprietors: |
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- INSERM (Institut National de la Santé
et de la Recherche Médicale)
75654 Paris Cedex 13 (FR)
- CENTRE NATIONAL DE
LA RECHERCHE SCIENTIFIQUE -CNRS-
75794 Paris Cedex 16 (FR)
- Université de Montpellier
34090 Montpellier (FR)
|
|
| (72) |
Inventors: |
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- HOLLANDE, Frédéric
F-34880 Laverune (FR)
- JOUBERT, Dominique
F-34400 Saturargues (FR)
- JAY, Philippe
F-34980 Combaillaux (FR)
- PANNEQUIN, Julie
F-34200 Sète (FR)
- DELAUNAY, Nathalie
F-34090 Montpellier (FR)
- BOURGAUX, Jean-François
F-30980 Langlade (FR)
|
| (74) |
Representative: Regimbeau |
|
20, rue de Chazelles
75847 Paris Cedex 17
75847 Paris Cedex 17 (FR) |
| (56) |
References cited: :
WO-A-2004/089976
|
WO-A-2006/032980
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| |
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Protein Complex" CANCER CELL, US, vol. 5, no. 1, January 2004 (2004-01), pages 91-102,
XP002984831 ISSN: 1535-6108
- SIDDHESHWAR R K ET AL: "Plasma levels of progastrin but not amidated gastrin or glycine
extended gastrin are elevated in patients with colorectal carcinoma" GUT, vol. 48,
no. 1, January 2001 (2001-01), pages 47-52, XP002398546 ISSN: 0017-5749
- KOYAMA TORU ET AL: "Mutation and expression of the beta-catenin-interacting protein
ICAT in human colorectal tumors." JAPANESE JOURNAL OF CLINICAL ONCOLOGY, vol. 32,
no. 9, September 2002 (2002-09), pages 358-362, XP002398547 ISSN: 0368-2811
- SINGH P ET AL: "INCOMPLETE PROCESSING OF PROGASTRIN EXPRESSED BY HUMAN COLON CANCER
CELLS: ROLE OF NONCARBOXYAMIDATED GASTRINS" AMERICAN JOURNAL OF PHYSIOLOGY, AMERICAN
PHYSIOLOGICAL SOCIETY, BETHESDA, MD, US, vol. 266, no. 3,PART 1, 1994, pages G459-G468,
XP009057913 ISSN: 0002-9513
- P. D. OTTEWELL: "COOH-terminal 26-amino acid residues of progastrin are sufficient
for stimulation of mitosis in murine colonic epithelium in vivo", AMERICAN JOURNAL
OF PHYSIOLOGY: GASTROINTESTINAL AND LIVER PHYSIOLOGY, vol. 288, no. 3, 21 October
2004 (2004-10-21), pages G541-G549, XP055013222, ISSN: 0193-1857, DOI: 10.1152/ajpgi.00268.2004
- SINGH POMILA ET AL: "Mice overexpressing progastrin are predisposed for developing
aberrant colonic crypt foci in response to AOM", 20000301, vol. 278, no. 3 part 1,
1 March 2000 (2000-03-01), pages G390-G399, XP002188103,
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