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(11)

EP 2 041 283 A1

(12)

(43) Date of publication: 01.04.2009 Bulletin 2009/14 (21) Application number: 07763819.5 (22) Date of filing: 26.06.2007

(51) International Patent Classification (IPC):  C12N 15/12(2006.01) A61K 38/17(2006.01) A61P 35/00(2006.01) C07K 7/06(2006.01) C12P 21/02(2006.01) A61K 31/7088(2006.01) A61K 48/00(2006.01) C07K 14/47(2006.01) C12N 15/63(2006.01) (86) International application number: PCT/CA2007/001150 (87) International publication number: WO 2008/000079 (03.01.2008 Gazette 2008/01)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 26.06.2006 US 816316 P (71) Applicant: THE UNIVERSITY OF BRITISH COLUMBIA Vancouver, British Columbia V6T 1Z3 (CA)	(72) Inventor: TAI, Isabella, T. Vancouver, British Columbia V5Z 1L3 (CA) (74) Representative: Hatzmann, Martin et al Vereenigde Johan de Wittlaan 7 2517 JR Den Haag 2517 JR Den Haag (NL)