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(11)

EP 2 043 598 A1

(12)

(43) Date of publication: 08.04.2009 Bulletin 2009/15 (21) Application number: 06774554.7 (22) Date of filing: 30.06.2006

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 9/22(2006.01) A61K 9/28(2006.01) A61K 9/44(2006.01) A61K 9/20(2006.01) A61K 9/24(2006.01) A61K 9/30(2006.01) (86) International application number: PCT/US2006/026432 (87) International publication number: WO 2008/005020 (10.01.2008 Gazette 2008/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (71) Applicant: Board of Trustees of the University of Arkansas Little Rock, AR 72207-3608 (US)	(72) Inventor: KIM, Cherng-Ju Little Rock, AR 72223 (US) (74) Representative: Ellis, Katherine Elizabeth Sleigh et al Williams Powell Staple Court 11 Staple Inn Buildings London, WC1V 7QH London, WC1V 7QH (GB)