(19)

(11)

EP 2 044 066 A2

(12)

(88) Date of publication A3: 17.07.2008 (43) Date of publication: 08.04.2009 Bulletin 2009/15 (21) Application number: 07795829.6 (22) Date of filing: 06.06.2007

(51) International Patent Classification (IPC):  C07D 417/14(2006.01) A61K 31/427(2006.01) A61P 31/00(2006.01) (86) International application number: PCT/US2007/013384 (87) International publication number: WO 2007/146039 (21.12.2007 Gazette 2007/51)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 06.06.2006 US 811482 P (71) Applicant: Bristol-Myers Squibb Company Princeton NJ 08543-4000 (US)	(72) Inventors: GOUGOUTAS, Jack, Z. Princeton, NJ 08540 (US) MALLEY, Mary, F. Lawrenceville, NJ 08648 (US) DIMARCO, John, D. East Brunswick, NJ 08816 (US) KIM, Soojin Demarest, NJ 07627 (US) XIAO, Hai-yun Belle Mead, NJ 08502 (US) MISRA, Raj, Narain Hopewell, NJ 08525 (US) (74) Representative: Ritter, Thomas Kurt  Jones Day Prinzregentenstraße 11 80538 München 80538 München (DE)