(19)

(11)

EP 2 044 437 A2

(12)

(88) Date of publication A3: 07.02.2008 (43) Date of publication: 08.04.2009 Bulletin 2009/15 (21) Application number: 07798658.6 (22) Date of filing: 15.06.2007

(51) International Patent Classification (IPC):  G01N 33/53(2006.01) (86) International application number: PCT/US2007/071382 (87) International publication number: WO 2007/147141 (21.12.2007 Gazette 2007/51)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 15.06.2006 US 813838 P (71) Applicant: Van Andel Research Institute Grand Rapids, MI 49503 (US)	(72) Inventor: HAAB, Brian, B. Jenison, MI 49428 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co., 14 South Square, Gray's Inn London, WC1R 5JJ London, WC1R 5JJ (GB)