(19)
(11) EP 2 048 228 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
11.05.2016 Bulletin 2016/19

(45) Mention of the grant of the patent:
23.03.2016 Bulletin 2016/12

(21) Application number: 08019659.5

(22) Date of filing: 19.01.2000
(51) International Patent Classification (IPC): 
C12N 5/071(2010.01)
 A61K 35/12(2006.01)

(54)

Human liver progenitors

Humane Lebervorläufer

Progéniteurs de foie humain

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 19.01.1999 US 116331 P

(43) Date of publication of application:
15.04.2009 Bulletin 2009/16

(62) Application number of the earlier application in accordance with Art. 76 EPC:
00906940.2 / 1147179

(73) Proprietor: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Chapel Hill NC 27517 (US)

(72) Inventors:
  • Reid, Lola M.
    Chapel Hill, NC 27514 (US)
  • Kubota, Hiroshi
    Chapel Hill NC 27514-8668 (US)
  • Moss, Nicholas
    Carrboro, NC 27510 (US)

(74) Representative: Mai, Dörr, Besier 
Patentanwälte Steuerberater/Wirtschaftsprüfer Kreuzberger Ring 64
65205 Wiesbaden
65205 Wiesbaden (DE)


(56) References cited: : 
US-A- 5 789 246
   
  • LEMMER E R ET AL: "Isolation from human fetal liver of cells co-expressing CD34 haematopoietic stem cell and CAM 5.2 pancytokeratin markers." JOURNAL OF HEPATOLOGY SEP 1998, vol. 29, no. 3, September 1998 (1998-09), pages 450-454, XP002970831 ISSN: 0168-8278
  • NAKAGOMI O ET AL: "Morphological and functional studies of human fetal liver cells in primary monolayer culture." THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE NOV 1980, vol. 132, no. 3, November 1980 (1980-11), pages 277-287, XP002040997 ISSN: 0040-8727
  • SUSICK R ET AL: "Hepatic progenitors and strategies for liver cell therapies." ANNALS OF THE NEW YORK ACADEMY OF SCIENCES NOV 2001, vol. 944, November 2001 (2001-11), pages 398-419, XP002420108 ISSN: 0077-8923
  • NYAMATH PARVEEN ET AL: "Characterization of hepatic progenitors from human fetal liver using CD34 as a hepatic progenitor marker.", WORLD JOURNAL OF GASTROENTEROLOGY : WJG 28 APR 2007 LNKD- PUBMED:17511030, vol. 13, no. 16, 28 April 2007 (2007-04-28), pages 2319-2323, ISSN: 1007-9327
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).