(19)

(11)

EP 2 049 666 A2

(12)

(88) Date of publication A3: 16.10.2008 (43) Date of publication: 22.04.2009 Bulletin 2009/17 (21) Application number: 07813317.0 (22) Date of filing: 25.07.2007

(51) International Patent Classification (IPC):  C12N 15/11(2006.01) A61K 31/7105(2006.01) A61K 39/00(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2007/074277 (87) International publication number: WO 2008/014296 (31.01.2008 Gazette 2008/05)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 28.07.2006 US 833879 P (71) Applicant: Sanofi-Aventis 75013 Paris (FR)	(72) Inventors: AUGUST, Paul Bridgewater, NJ 08807 (US) HUANG, Waan Jeng Bridgewater, NJ 08807 (US) NATESAN, Sridaran Bridgewater, NJ 08807 (US) LIEBERMAN, Soyan Bridgewater, NJ 08807 (US) (74) Representative: Le Pennec, Magali et al Sanofi-Aventis Direction Brevets 174 Avenue de France 75013 Paris 75013 Paris (FR)