(19)

(11)

EP 2 051 737 A2

(12)

(88) Date of publication A3: 03.04.2008 (43) Date of publication: 29.04.2009 Bulletin 2009/18 (21) Application number: 07796994.7 (22) Date of filing: 24.07.2007

(51) International Patent Classification (IPC):  A61K 47/12(2006.01) A61K 9/08(2006.01) A61K 9/12(2006.01) A61K 9/16(2006.01) A61K 31/506(2006.01) A61K 9/10(2006.01) A61K 9/14(2006.01) A61K 9/00(2006.01) (86) International application number: PCT/US2007/016637 (87) International publication number: WO 2008/013807 (31.01.2008 Gazette 2008/05)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 26.07.2006 US 833442 P (71) Applicant: Merck & Co., Inc. Rahway, NJ 07065-0907 (US)	(72) Inventor: DUBOST, David, C. Rahway, New Jersey 07065-0907 (US) (74) Representative: Hussain, Deeba  Merck & Co., Inc. Hertford Road Hoddesdon Hertfordshire EN11 9BU Hoddesdon Hertfordshire EN11 9BU (GB)