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EP 2 051 982 A1

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(43) Date of publication: 29.04.2009 Bulletin 2009/18 (21) Application number: 06801288.9 (22) Date of filing: 10.08.2006

(51) International Patent Classification (IPC):  C07D 495/04(2006.01) A61P 35/00(2006.01) A61K 31/519(2006.01) (86) International application number: PCT/US2006/031433 (87) International publication number: WO 2008/018881 (14.02.2008 Gazette 2008/07)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (71) Applicant: OSI Pharmaceuticals, Inc. Melville, NY 11747 (US)	(72) Inventors: JI, Qun-Sheng Farmingdale, NY 11735 (US) MULVIHILL, Mark, Joseph Farmingdale, NY 11735 (US) STEINIG, Arno, G. Farmingdale, NY 11735 (US) WENG, Qinghua Farmingdale, NY 11735 (US) (74) Representative: Blakey, Alison Jane  Prosidion Limited Windrush Court Watlington Road Oxford OX4 6LT Oxford OX4 6LT (GB)