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(11)

EP 2 051 984 A1

(12)

(43) Date of publication: 29.04.2009 Bulletin 2009/18 (21) Application number: 07799771.6 (22) Date of filing: 24.07.2007

(51) International Patent Classification (IPC):  C07D 498/18(2006.01) A61P 37/06(2006.01) A61K 31/395(2006.01) A61K 31/4353(2006.01) (86) International application number: PCT/US2007/074159 (87) International publication number: WO 2008/014222 (31.01.2008 Gazette 2008/05)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 25.07.2006 US 820317 P 23.07.2007 US 781804 23.07.2007 US 781807 (71) Applicant: ABBOTT LABORATORIES Abbott Park, IL 60064 (US)

(72) Inventors: VISWANATH, Shekhar Vernon Hills, IL 60061 (US) BARTELT, Larry Highland Park, IL 60035 (US) LEANNA, Robert Grayslake, IL 60030 (US) RASMUSSEN, Michael Racine, WI 53403 (US) DHAON, Madhup Mundelein, IL 60060 (US) HENRY, Rodger Wildwood, IL 60030 (US) BORCHARDT, Thomas Kenosha, WI 53144 (US) CHEN, Shuang Gumee, IL 60031 (US) ZHANG, Geoff Liberyville, IL 60048 (US) (74) Representative: Barlocci, Anna  ZBM Patents, S.L. Balmes, 114 4° 08008 Barcelona 08008 Barcelona (ES)