RNA INTERFERENCE MEDIATED INHIBITION OF PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9 (PCSK9) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) - Patent 2052079

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EP 2 052 079 A2

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(88)	Date of publication A3:
	17.07.2008

(43)	Date of publication:
	29.04.2009 Bulletin 2009/18

(21)	Application number: 07813032.5

(22)	Date of filing: 17.07.2007

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International Patent Classification (IPC):

C12N 15/11^(2006.01)

(86)	International application number:
	PCT/US2007/073723

(87)	International publication number:
	WO 2008/011431 (24.01.2008 Gazette 2008/04)

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
	Designated Extension States:
	AL BA HR MK RS

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Priority:

17.07.2006 US 487788
28.11.2006 US 861369 P

(71)	Applicant: Sirna Therapeutics Inc.
	San Francisco, CA 94158 (US)

(72)	Inventors:
	MCSWIGGEN, James Boulder, CO 80301 (US) JADHAV, Vasant Longmont, CO 80503 (US) VAISH, Narendra K. Denver, CO 80218 (US) GUERCIOLINI, Roberto Boulder, CO 80303 (US) VARGEESE, Chandra Broomfield, CO 80023 (US)

(74)	Representative: Hussain, Deeba
	Merck & Co., Inc. Hertford Road Hoddesdon Hertfordshire EN11 9BU Hoddesdon Hertfordshire EN11 9BU (GB)

(54)	RNA INTERFERENCE MEDIATED INHIBITION OF PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9 (PCSK9) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)