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(11)

EP 2 057 162 A2

(12)

(88) Date of publication A3: 31.07.2008 (43) Date of publication: 13.05.2009 Bulletin 2009/20 (21) Application number: 07796659.6 (22) Date of filing: 02.07.2007

(51) International Patent Classification (IPC):  C07D 487/04(2006.01) C07D 495/04(2006.01) A61K 31/381(2006.01) A61K 31/429(2006.01) A61P 25/00(2006.01) C07D 491/04(2006.01) C07D 513/04(2006.01) A61K 31/407(2006.01) A61K 31/4162(2006.01) (86) International application number: PCT/US2007/015396 (87) International publication number: WO 2008/005456 (10.01.2008 Gazette 2008/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 30.06.2006 US 806391 P 05.09.2006 US 842465 P 26.04.2007 US 914293 P (71) Applicant: Sepracor Inc. Marlborough, MA 01752-7010 (US)

(72) Inventors: DORSEY, James, M. Durham, NC 27703 (US) HOPKINS, Seth, C. Clinton, MA 01510 (US) FOGLESONG, Robert, J. Durham, NC 27712 (US) HEFFERNAN, Michele, L.r. Woreester, MA 01605 (US) JONES, Michael, L. Chaple Hill, NC 27514 (US) PERALES, Joseph, B. Durham, NC 27713 (US) FANG, Qun, Kevin Wellesley, MA 02482 (US) OGBU, Cyprian, O. Durham, NC 27703 (US) JONES, Steven, W. Milford, MA 01757 (US) SOUKRI, Mustapha Raleigh, NC (US) VARNEY, Mark, A. Laguna Niguel, CA 92677 (US) SPEAR, Kerry, L. Concord, MA 01742 (US) (74) Representative: Harrison Goddard Foote  Belgrave Hall Belgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)