(19)

(11)

EP 2 057 190 A2

(12)

(88) Date of publication A3: 13.11.2008 (43) Date of publication: 13.05.2009 Bulletin 2009/20 (21) Application number: 07840833.3 (22) Date of filing: 09.08.2007

(51) International Patent Classification (IPC):  C07K 16/00(2006.01) A61K 39/395(2006.01) C12P 21/08(2006.01) G01N 33/53(2006.01) (86) International application number: PCT/US2007/075616 (87) International publication number: WO 2008/021976 (21.02.2008 Gazette 2008/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 09.08.2006 US 836599 P (71) Applicant: Baylor Research Institute Dallas, TX 75204 (US)	(72) Inventors: BANCHEREAU, Jacques Dallas, TX 75223 (US) PRILLIMAN, Kiley Abilena, TX 79605 (US) PASCUAL, Virginia Dallas, TX 75252 (US) PALUCKA, Anna Karolina Dallas, TX 75204 (US) (74) Representative: Harrison Goddard Foote  Belgrave Hall Belgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)