(19)

(11)

EP 2 057 278 A2

(12)

(88) Date of publication A3: 22.05.2008 (43) Date of publication: 13.05.2009 Bulletin 2009/20 (21) Application number: 07811572.2 (22) Date of filing: 28.08.2007

(51) International Patent Classification (IPC):  C12Q 1/37(2006.01) C12Q 1/70(2006.01) (86) International application number: PCT/US2007/018945 (87) International publication number: WO 2008/027397 (06.03.2008 Gazette 2008/10)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 28.08.2006 US 840573 P (71) Applicant: Vertex Pharmceuticals Incorporated Cambridge, MA 02139-4242 (US)	(72) Inventor: TAYLOR, William, P. Littleton, MA 01460 (US) (74) Representative: Cohausz & Florack  Patent- und Rechtsanwälte Bleichstraße 14 40211 Düsseldorf 40211 Düsseldorf (DE)