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(11)

EP 2 057 284 A1

(12)

(43) Date of publication: 13.05.2009 Bulletin 2009/20 (21) Application number: 07840710.3 (22) Date of filing: 06.08.2007

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) C07H 21/04(2006.01) A01N 43/04(2006.01) A61K 31/07(2006.01) (86) International application number: PCT/US2007/075301 (87) International publication number: WO 2008/017081 (07.02.2008 Gazette 2008/06)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 04.08.2006 US 835822 P (71) Applicant: Isis Pharmaceuticals, Inc. Carlsbad, CA 92008 (US)	(72) Inventors: YU, Xiag-Xian San Diego, CA 92130 (US) BHANOT, Sanjay Carlsbad, CA 92009 (US) (74) Representative: Hallybone, Huw George et al Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)