(19)

(11)

EP 2 068 877 A2

(12)

(88) Date of publication A3: 14.08.2008 (43) Date of publication: 17.06.2009 Bulletin 2009/25 (21) Application number: 07840438.1 (22) Date of filing: 19.07.2007

(51) International Patent Classification (IPC):  A61K 31/47(2006.01) C07D 215/20(2006.01) C07D 215/16(2006.01) (86) International application number: PCT/US2007/073877 (87) International publication number: WO 2008/011513 (24.01.2008 Gazette 2008/04)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 19.07.2006 US 831992 P (71) Applicant: The Cleveland Clinic Foundation Cleveland OH 44195 (US)	(72) Inventors: BYZOVA, Tatiana Pepper Pike, OH 44124 (US) BHAT, Ganapati Cleveland, OH 44120 (US) FENG, Weiy Woodmere, OH 44122 (US) (74) Representative: Chapman, Paul Gilmour et al Marks & Clerk LLP 19 Royal Exchange Square Glasgow G1 3AE Glasgow G1 3AE (GB)