(19)

(11)

EP 2 069 296 A2

(12)

(88) Date of publication A3: 22.05.2008 (43) Date of publication: 17.06.2009 Bulletin 2009/25 (21) Application number: 07843117.8 (22) Date of filing: 25.09.2007

(51) International Patent Classification (IPC):  C07C 401/00(2006.01) A61P 35/00(2006.01) A61P 17/06(2006.01) A61P 29/00(2006.01) A61P 3/04(2006.01) A61K 31/59(2006.01) A61P 35/02(2006.01) A61P 37/06(2006.01) A61P 17/00(2006.01) (86) International application number: PCT/US2007/079381 (87) International publication number: WO 2008/039751 (03.04.2008 Gazette 2008/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 28.09.2006 US 848805 P (71) Applicant: Wisconsin Alumni Research Foundation Madison, WI 53075 (US)	(72) Inventors: DELUCA, Hector F. Deerfield, WI 53531 (US) CLAGETT-DAME, Margaret Deerfield, WI 53531 (US) PLUM, Lori A. Arena, WI 53503 (US) CHIELLINI, Grazia Madison, WI 53705 (US) GRZYWACZ, Pawel Madison, WI 53703 (US) (74) Representative: Spencer, Matthew Peter  Boult Wade Tennant Verulam Gardens 70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)