ATBECHDEDKESFRGBGRITLILUNLSEMCPTIE......FI..........................................................JDIM360 Ver 2.15 (14 Jul 2008) - 2999001/02070920CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120110427W172deBibliographieenBibliographyfrBibliographieEP09151443.0199707242009121020100113enenen69025819960724US70149419960822US48278 P19970530US2011042720111720090617200925201103022011092010111620110427201117C07D 401/04 20060101AFI20090504BHEP A61K 31/445 20060101ALI20090504BHEP deSubstituierte 2-(2,6-Dioxopiperidin-3-yl)-phthalimide und Oxoisoindoline und Verfahren zur Verringerung der TNF-Alpha-StufenenSubstituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxoisoindolines and method of reducing TNF alpha levelsfr2-(2,6-dioxopipéridin-3-yl)-phtalimides et 1-oxoisoindolines substituées et procédé pour réduire les niveaux de TNF alphaWO-A-98/03502US-A- 5 463 063US-A- 5 635 517NIWAYAMA S ET AL: "POTENT INHIBITION OF TUMOR NECROSIS FACTOR-ALPHA PRODUCTION BY TETRAFLUOROTHALIDOMIDE AND TETRAFLUOROPHTHALAMIDES" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON., US, vol. 39, no. 16, 1 January 1996 (1996-01-01), page 3044/3045, XP002048231 ISSN: 0022-2623HE WEIXUAN ET AL: "Synthesis of thalidomide analogs and their biological potential for treatment of graft versus host disease." ABSTRACTS OF PAPERS AMERICAN CHEMICAL SOCIETY, vol. 206, no. 1-2, 1993, page MEDI 216, XP009001980 206th ACS;Chicago, Illinois, USA; August 22-27, 1993 ISSN: 0065-7727WNENDT ET AL: "Enantioselective inhibition of TNF-.alpha. release by thalidomide and thalidomide-analogs" CHIRALITY, WILEY-LISS, NEW YORK, US, vol. 8, 1996, pages 390-396, XP002074569 ISSN: 0899-0042MIYACHI H ET AL: "Tumor necrosis factor-alpha production enhancing activity of substituted 3'-methylthalidomide: Influence of substituents at the phthaloyl moiety on the activity and stereoselectivity" CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, JP, vol. 46, no. 7, July 1998 (1998-07), pages 1165-1168, XP002107774 ISSN: 0009-2363MULLER GEORGE W ET AL: "Amino-substituted thalidomide analogs: Potent inhibitors of TNF-alpha production." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 11, 7 June 1999 (1999-06-07), pages 1625-1630, XP004169632 ISSN: 0960-894X02012942.512859162002061197936295.109252941998012910183268.1230566320100930Muller, George WP.O.Box 3688Rancho Santa Fe, CA 92067USStirling, David3281 Round Hill RoadBranchburg, NJ 08876USChen, Roger, Shen-Chu110 Christie StreetEdison, NJ 08820USCELGENE CORPORATION100096655AXH/47056EP37 Powder Horn DriveWarren, NJ 07059USHutter, Antonet al101053823Venner Shipley LLP 20 Little BritainLondon EC1A 7DHGBATBECHDEDKESFIFRGBGRIEITLILUMCNLPTSE20090617200925