(19)

(11)

EP 2 074 098 A2

(12)

(88) Date of publication A3: 24.07.2008 (43) Date of publication: 01.07.2009 Bulletin 2009/27 (21) Application number: 07844372.8 (22) Date of filing: 18.10.2007

(51) International Patent Classification (IPC):  C07D 215/14(2006.01) C07D 215/48(2006.01) C07D 401/12(2006.01) C07D 413/10(2006.01) C07D 495/04(2006.01) A61K 31/4709(2006.01) C07D 215/18(2006.01) C07D 401/04(2006.01) C07D 409/04(2006.01) C07D 413/12(2006.01) C07F 7/18(2006.01) A61P 9/10(2006.01) (86) International application number: PCT/US2007/081738 (87) International publication number: WO 2008/049047 (24.04.2008 Gazette 2008/17)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 18.10.2006 US 852588 P (71) Applicant: Wyeth Madison, NJ 07940 (US)

(72) Inventors: BERNOTAS, Ronald Charles Royersford, Pennsylvania 19468 (US) SINGHAUS, Robert Ray Jr. Pottstown, Pennsylvania 19464 (US) ULLRICH, John William Downingtown, Pennsylvania 19335 (US) KAUFMAN, David Harry Schwenksville, Pennsylvania 19473 (US) MORRIS, Robert Lester Wayne, Pennsylvania 19087 (US) WROBEL, Jay E. Lawrenceville, New Jersey 08648 (US) HU, Baihua Audubon, Pennsylvania 19403 (US) JETTER, James Winfield Norristown, Pennsylvania 19403 (US) COLLINI, Michael David Clifton Heights, Pennsylvania 19018 (US) TRAVINS, Jeremy Mark Downingtown, Pennsylvania 19335 (US) MAGOLDA, Ronald Louis Wallingford, Pennsylvania 19086 (US) (74) Representative: Fletcher, Rodney Justin  Wyeth Pharmaceuticals Patent & Trade Marks Department Huntercombe Lane South Taplow GB-Maidenhead, Berkshire SL6 0PH GB-Maidenhead, Berkshire SL6 0PH (GB)