(19)

(11)

EP 2 074 107 A2

(12)

(88) Date of publication A3: 08.01.2009 (43) Date of publication: 01.07.2009 Bulletin 2009/27 (21) Application number: 07839790.8 (22) Date of filing: 26.10.2007

(51) International Patent Classification (IPC):  C07D 307/91(2006.01) C07D 405/04(2006.01) C07D 409/14(2006.01) C07D 413/12(2006.01) A61K 31/343(2006.01) A61K 31/443(2006.01) A61K 31/4192(2006.01) A61K 31/496(2006.01) C07D 333/76(2006.01) C07D 409/12(2006.01) C07D 413/04(2006.01) C07D 417/04(2006.01) A61K 31/381(2006.01) A61K 31/4155(2006.01) A61K 31/5377(2006.01) (86) International application number: PCT/US2007/022651 (87) International publication number: WO 2008/057254 (15.05.2008 Gazette 2008/20)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 27.10.2006 US 854786 P (71) Applicant: Wyeth Madison, NJ 07940 (US)

(72) Inventors: LI, Wei Acton, MA 01720 (US) LI, Jianchang Carlisle, MA 01720 (US) WU, Yuchuan Acton, MA 01720 (US) TAM, Steve Wellesley, MA 02484 (US) MANSOUR, Tarek New City, NY 10956 (US) SYPEK, Joseph P. Waban, MA 02468 (US) MCFAYDEN, Iain Medford, MA 02155 (US) HOTCHANDANI, Rajeev Watertown, MA 02472 (US) WU, Junjun Billerica, MA 01821 (US) (74) Representative: Talbott, Dawn Jacqueline  Wyeth Pharmaceuticals, Huntercombe Lane South, Taplow Maidenhead, Berkshire SL6 0PH Maidenhead, Berkshire SL6 0PH (GB)