(19)
(11) EP 2 078 001 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
15.12.2010 Bulletin 2010/50

(45) Mention of the grant of the patent:
12.05.2010 Bulletin 2010/19

(21) Application number: 07818740.8

(22) Date of filing: 05.10.2007
(51) International Patent Classification (IPC): 
C07D 243/08(2006.01)
A61P 3/00(2006.01)
 A61K 31/551(2006.01)
(86) International application number:
PCT/EP2007/008664
(87) International publication number:
WO 2008/052638 (08.05.2008 Gazette 2008/19)

(54)

DIAZEPANE-ACETAMIDE DERIVATIVES AS SELECTIVE 11 -HSD1 INHIBITORS

DIAZEPAN-ACETAMIDDERIVATE ALS SELEKTIVE 11-HSD1-HEMMER

DÉRIVÉS DE DIAZÉPANE-ACÉTAMINE EN TANT QU'INHIBITEURS SÉLECTIFS DE 11 -HSD1

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

(30) Priority: 03.11.2006 EP 06291704

(43) Date of publication of application:
15.07.2009 Bulletin 2009/29

(73) Proprietor: Merck Patent GmbH
64293 Darmstadt (DE)

(72) Inventors:
  • CARNIATO, Denis
    F-91460 Marcoussis (FR)
  • LERICHE, Caroline
    F-75014 Paris (FR)
  • ROCHE, Didier
    F-91400 Saclay (FR)
  • CHARON, Christine
    F-91940 Gometz-le-Chatel (FR)
  • DOARE, Liliane
    F-91170 Viry-Chatillon (FR)


(56) References cited: : 
WO-A-98/46591
WO-A-2004/033427
WO-A-2005/063247
WO-A-2006/094633
 WO-A-98/46628
WO-A-2004/056745
WO-A-2006/012226
   
  • BARF T ET AL: "Recent progress in 11-[beta]-hydroxysteroid dehydrogenase type 1 (11-[beta]-HSD1) inhibitor development" DRUGS OF THE FUTURE, BARCELONA, ES, vol. 31, no. 3, March 2006 (2006-03), pages 231-243, XP002424785 ISSN: 0377-8282
  • FOTSCH C ET AL: "11[beta]-Hydroxysteroid dehydrogenase-1 as a therapeutic target for metabolic diseases" EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 15, no. 3, 2005, pages 289-303, XP002376609 ISSN: 1354-3776
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).