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(11)

EP 2 078 018 A1

(12)

(43) Date of publication: 15.07.2009 Bulletin 2009/29 (21) Application number: 07861468.2 (22) Date of filing: 18.10.2007

(51) International Patent Classification (IPC):  C07D 473/00(2006.01) A61K 31/519(2006.01) A61P 29/00(2006.01) C07D 475/00(2006.01) A61K 31/522(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2007/022375 (87) International publication number: WO 2008/051494 (02.05.2008 Gazette 2008/18)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 19.10.2006 US 853135 P (71) Applicant: Signal Pharmaceuticals LLC San Diego, CA 92121 (US)

(72) Inventors: MORTENSEN, Deborah Sue San Diego, CA 92117 (US) MEDEROS, Maria Mercedes Delgado San Diego, CA 92126 (US) SAPIENZA, John Joseph Chula Vista, CA 91913 (US) ALBERS, Ronald J. San Diego, CA 92111 (US) LEE, Branden G. Vista, CA 92081 (US) HUANG, Dehua San Diego, CA 92130 (US) SCHWARZ, Kimberly Lyn San Diego, CA 92117 (US) PARNES, Jason Simon San Diego, CA 92130 (US) RIGGS, Jennifer R. Cardiff, CA 92007 (US) PAPA, Patrick William Carlsbad, CA 92010 (US) (74) Representative: Ritter, Thomas Kurt  Jones Day Prinzregentenstraße 11 D-80538 München D-80538 München (DE)