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(11)

EP 2 078 027 A1

(12)

(43) Date of publication: 15.07.2009 Bulletin 2009/29 (21) Application number: 07844341.3 (22) Date of filing: 17.10.2007

(51) International Patent Classification (IPC):  C07D 498/08(2006.01) A61P 11/06(2006.01) A61P 19/10(2006.01) A61P 37/00(2006.01) A61K 31/395(2006.01) A61P 19/02(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2007/081635 (87) International publication number: WO 2008/051763 (02.05.2008 Gazette 2008/18)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 23.10.2006 US 862500 P (71) Applicant: IRM LLC Hamilton HM LX (BM)	(72) Inventors: EPPLE, Robert San Diego, CA 92122 (US) RUSSO, Ross Encinitas, CA 92024 (US) (74) Representative: Kiddle, Simon John  Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS London EC2V 8AS (GB)