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EP 2 079 699 A1

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(43) Date of publication: 22.07.2009 Bulletin 2009/30 (21) Application number: 07815779.9 (22) Date of filing: 25.07.2007

(51) International Patent Classification (IPC):  C07D 215/24(2006.01) A61K 31/4709(2006.01) C07D 215/26(2006.01) C07D 215/16(2006.01) C07D 413/06(2006.01) A61K 31/47(2006.01) A61K 31/5377(2006.01) C07D 215/28(2006.01) C07D 401/06(2006.01) (86) International application number: PCT/CA2007/001324 (87) International publication number: WO 2008/014602 (07.02.2008 Gazette 2008/06)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 25.07.2006 US 832937 P (71) Applicant: Envivo Pharmaceuticals, Inc. Watertown, MA 02472 (US)

(72) Inventors: HEKIMI, Siegfried Montreal, Quebec H4P 1E5 (CA) McBRIDE, Kevin Montreal, Quebec H2Y 2H3 (CA) HIHI, Abdelmadjid, K. Montréal, Quebec H4A 3L5 (CA) KIANICKA, Irenej Rosemère, Québec J7A 3N4 (CA) WANG, Ying Montreal, Québec H3H 2A2 (CA) HAYES, Steven Leonard Montreal, Québec H2R 2C7 (CA) GUIMOND, Marie-Pierre Montréal, Québec H1V 2T2 (CA) SÉVIGNY, Guy Montreal, Québec H2C 1W5 (CA) DUMAS, Daniel Marhamchurch, Cornwall EX23 OHD (GB) SMITH, Julian Exeter, Devon EX4 2JJ (GB) (74) Representative: Peterreins, Frank  Fish & Richardson P.C. Highlight BusinessTowers Mies-van-der-Rohe-Strasse 8 80807 München 80807 München (DE)