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EP 2 079 728 A1

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(43) Date of publication: 22.07.2009 Bulletin 2009/30 (21) Application number: 07839443.4 (22) Date of filing: 09.10.2007

(51) International Patent Classification (IPC):  C07D 401/14(2006.01) C07D 409/14(2006.01) C07D 471/04(2006.01) A61K 31/506(2006.01) C07D 403/04(2006.01) C07D 417/14(2006.01) C07D 487/04(2006.01) A61P 3/10(2006.01) (86) International application number: PCT/US2007/021678 (87) International publication number: WO 2008/045484 (17.04.2008 Gazette 2008/16)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 10.10.2006 US 851083 P (71) Applicant: Amgen Inc. Thousand Oaks, CA 91320-1799 (US)

(72) Inventors: OGAWA, Yasuyuki Shinagawa-ku, Tokyo (JP) OKUYAMA, Ryo Tokyo (JP) SHIBUYA, Satoshi Shinagawa-ku, Tokyo (JP) TODA, Narihiro Tokyo (JP) CAO, Zhaodan Brisbane, CA 94005 (US) FU, Zice Foster City, CA 94404 (US) HAO, Xiaolin Foster City, CA 94404 (US) KIM, Yong-jae Foster City, CA 94404 (US) LI, Leping Burlingame, CA 94010 (US) LIVELY, Sarah E. San Carlos, CA 94070 (US) LIZARZABURU, Mike San Diego, CA 92115 (US) TIAN, Hui Foster City, CA 94404 (US) YU, Ming Foster City, CA 94404 (US) (74) Representative: Ritter, Thomas Kurt et al Jones Day Prinzregentenstraße 11 80538 München 80538 München (DE)