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(11)

EP 2 081 563 A1

(12)

(43) Date of publication: 29.07.2009 Bulletin 2009/31 (21) Application number: 07844238.1 (22) Date of filing: 12.10.2007

(51) International Patent Classification (IPC):  A61K 31/192(2006.01) A61K 9/28(2006.01) A61K 9/20(2006.01) A61K 9/16(2006.01) (86) International application number: PCT/US2007/081267 (87) International publication number: WO 2008/046052 (17.04.2008 Gazette 2008/16)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 12.10.2006 US 829255 P (71) Applicant: ABBOTT LABORATORIES Abbott Park IL 60064-3500 (US)	(72) Inventors: GAO, Yi Vernon Hills, IL 60061 (US) TZUCHI, R. Ju Vernon Hills, IL 60061 (US) LEE, Dennis Y. Highland Park, IL 60035 (US) NGUYEN, Nicole Winfield, IL 60190 (US) WU, Hauiliang Long Grove, IL 60047 (US) (74) Representative: Hart-Davis, Jason et al Cabinet Beau de Loménie, 158, rue de l'Université 75340 Paris Cedex 07 75340 Paris Cedex 07 (FR)