(19)

(11)

EP 2 083 859 A2

(12)

(88) Date of publication A3: 11.12.2008 (43) Date of publication: 05.08.2009 Bulletin 2009/32 (21) Application number: 07861680.2 (22) Date of filing: 02.11.2007

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) C07K 16/40(2006.01) (86) International application number: PCT/US2007/023212 (87) International publication number: WO 2008/057457 (15.05.2008 Gazette 2008/20)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 07.11.2006 US 857320 P (71) Applicant: Merck and Co., Inc. Rahway, NJ 07065 (US)	(72) Inventors: SPARROW, Carl P. Rahway, NJ 07065-0907 (US) SITLANI, Ayesha Rahway, NJ 07065-0907 (US) PANDIT, Shilpa Rahway, NJ 07065-0907 (US) CONDRA, Jon H. Rahway, NJ 07065-0907 (US) HAMMOND, Holly A. Rahway, NJ 07065-0907 (US) (74) Representative: Hussain, Deeba  Merck & Co., Inc. Hertford Road Hoddesdon Hertfordshire EN11 9BU Hoddesdon Hertfordshire EN11 9BU (GB)