(19)

(11)

EP 2 084 540 A2

(12)

(88) Date of publication A3: 07.08.2008 (43) Date of publication: 05.08.2009 Bulletin 2009/32 (21) Application number: 07871425.0 (22) Date of filing: 09.11.2007

(51) International Patent Classification (IPC):  G01N 33/574(2006.01) C07K 16/28(2006.01) C12Q 1/68(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2007/084293 (87) International publication number: WO 2008/061020 (22.05.2008 Gazette 2008/21)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 14.11.2006 US 858882 P (71) Applicant: Novartis AG 4056 Basel (CH)	(72) Inventors: LAI, Albert Emeryville, CA 94662-8097 (US) YU, Guoying, K. Emeryville, CA 94662-8097 (US) (74) Representative: Vögeli-Lange, Regina  Novartis Pharma AG Patent Department 4002 Basel 4002 Basel (CH)