(19)

(11)

EP 2 089 012 A2

(12)

(88) Date of publication A3: 10.07.2008 (43) Date of publication: 19.08.2009 Bulletin 2009/34 (21) Application number: 07864234.5 (22) Date of filing: 09.11.2007

(51) International Patent Classification (IPC):  A61K 31/165(2006.01) A61P 19/02(2006.01) C07C 237/22(2006.01) (86) International application number: PCT/US2007/084314 (87) International publication number: WO 2008/058278 (15.05.2008 Gazette 2008/20)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 09.11.2006 US 857779 P 09.11.2006 US 857794 P 09.11.2006 US 857791 P 09.11.2006 US 857790 P 09.11.2006 US 857781 P 09.11.2006 US 857780 P 09.11.2006 US 857793 P 09.11.2006 US 857792 P (71) Applicant: Wyeth Madison, NJ 07940 (US)

(72) Inventors: LIANG, Jennifer Q. Morris Plains, NJ 07950 (US) WANG, Qiuxia Trisha Nanuet, NY 10954 (US) KU, Mann-ching Sherry Thiells, NY 10984 (US) MICHALAK, Ronald S. Congers, NY 10920 (US) HUANG, W. James Hillsborough, NJ 08844 (US) (74) Representative: Talbott, Dawn Jacqueline  Wyeth Pharmaceuticals, Huntercombe Lane South, Taplow Maidenhead, Berkshire SL6 0PH Maidenhead, Berkshire SL6 0PH (GB)